Genome Property Definition Page

NameO111(Ec) antigen biosynthesis
DescriptionThe O111 O-antigen is observed in E. coli strain 11128. The structure of the O111 antigen is a branched pentasaccharide containing two colitose sugars [1]. The O111 biosynthetic cluster encodes three sugar transferases WbdHLM, the wzx and wzy components as well as the enzymes for the biosynthesis of GDP-L-colitose from D-fructose-6P via GDP-mannose. One of the transferases, WbdM, is responsible for attaching both colitose residues at both the 3 and 6 positions of alpha-D-glucose as the last steps of the monomer synthesis.
Parent PropertyGenProp0913: E. coli O-antigen monomer biosynthesis clusters
Literature References
[ 1 ]Stevenson G, Dieckelmann M, Reeves PR  Determination of glycosyltransferase specificities for the Escherichia coli O111 O antigen by a generic approach.  Appl Environ Microbiol. 2008 Feb;74(4):1294-8. Epub 2007 Dec 21.  PMID 18156323
Web ReferencesECODAB: O111

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
source of GDP-colitoseGDP-ColYESGenProp0946 (GENPROP): GDP-L-colitose biosynthesis
aDGal(1->3)bDGlcNAcWbdHYES2890 (RULE_BASE)
aDGlc(1->4)aDGalWbdLYES2755 (RULE_BASE)
aCol(1->3,6)aDGlcWbdMYES2754 (RULE_BASE)
O111-specific transporter (flippase)wzx111YES2891 (RULE_BASE)
O111-specific polymerasewzy111YES2756 (RULE_BASE)

Parent Properties
GenProp0913E. coli O-antigen monomer biosynthesis clusters

Sibling Properties
GenProp0932O104(Ec) antigen biosynthesis
GenProp0947O55(Ec) antigen biosynthesis
GenProp0953O103(Ec) antigen biosynthesis
GenProp0963O2(Ec) antigen biosynthesis
GenProp1014O5(Ec) antigen biosynthesis
GenProp1018O8(Ec) antigen biosynthesis
GenProp1042O128(Ec) antigen biosynthesis