Genome Property Definition Page

NameD-alanyl-lipoteichoic acid biosynthesis
DescriptionThe DltABCD operon, responsible for D-alanylation of LipoTeichoic acids (hence DLT) is near-universal in low-GC Gram-positive bacteria, although absent in Clostridium perfringens, Oceanobacillus iheyensis, etc. This Genome Property describes the DltABCD system, rather than LTA biosynthesis itself. Note that lipoteichoic acids (LTA), anionic polymers, are variable among species or strains, with backbones that often consist of polyglycerolphosphate (e.g. Staphylococcus aureus) but with additional modifications. LTA are covalently linked to membrane components, and differ from wall teichoic acids (WTA), such as the polyribitol phosphate WTAs in S. aureus and B. subtilis W23.
JCVI RoleBiosynthesis and degradation of murein sacculus and peptidoglycan
Literature References
[ 1 ]Osman KT, Du L, He Y, Luo Y  Crystal structure of Bacillus cereus D-alanyl carrier protein ligase (DltA) in complex with ATP.  J Mol Biol. 2009 May 1;388(2):345-55. Epub 2009 Mar 24.  PMID 19324056
[ 2 ]Kovacs M, Halfmann A, Fedtke I, Heintz M, Peschel A, Vollmer W, Hakenbeck R, Bruckner R  A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae.  J Bacteriol. 2006 Aug;188(16):5797-805.  PMID 16885447
Gene Ontology TermGO:0070394: lipoteichoic acid metabolic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
D-alanine-D-alanyl carrier protein ligasedltAYESTIGR01734 (HMM): D-alanine--poly(phosphoribitol) ligase, subunit 1GO:0070394: lipoteichoic acid metabolic process
D-alanyl-lipoteichoic acid biosynthesis protein DltBdltBYESTIGR04091 (HMM): D-alanyl-lipoteichoic acid biosynthesis protein DltBGO:0070394: lipoteichoic acid metabolic process
D-alanine-D-alanyl carrier proteindltCYESTIGR01688 (HMM): D-alanine--poly(phosphoribitol) ligase, subunit 2GO:0070394: lipoteichoic acid metabolic process
D-alanyl-lipoteichoic acid biosynthesis protein DltDdltDYESTIGR04092 (HMM): D-alanyl-lipoteichoic acid biosynthesis protein DltDGO:0070394: lipoteichoic acid metabolic process