Genome Property Definition Page

AccessionGenProp0962
Namemethanobactin biosynthesis, Mb-OB3b family
TypeSYSTEM
DescriptionMethanobactins are siderophore-like copper chelators. The charter member for this Genome Property is Methylosinus trichosporium OB3b, in which the methanobactin is made from a 30-residue ribosomally translated precursor. The only other system known so far is in Azospirillum sp. B510. Protein families TIGR04039, TIGR04052, and TIGR04061 contain proteins in which the Methylosinus and Azospirillum are mutually the best hits among all genomes, suggesting they act in the methanobactin system.
Parent PropertyGenProp0077: natural products biosynthesis
Literature References
[ 1 ]Krentz BD, Mulheron HJ, Semrau JD, Dispirito AA, Bandow NL, Haft DH, Vuilleumier S, Murrell JC, McEllistrem MT, Hartsel SC, Gallagher WH  A comparison of methanobactins from Methylosinus trichosporium OB3b and Methylocystis strain Sb2 predicts methanobactins are synthesized from diverse peptide precursors modified to create a common core for binding and reducing copper ions.  Biochemistry. 2010 Nov 30;49(47):10117-30.  PMID 20961038
Gene Ontology TermGO:0015677: copper ion import (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
methanobactin precursor, Mb-OB3b familymbnAYESTIGR04071 (HMM): methanobactin precursor, Mb-OB3b familyGO:0015677: copper ion import
methanobactin biosynthesis cassette protein MbnBmbnBYESTIGR04159 (HMM): methanobactin biosynthesis cassette protein MbnBGO:0015677: copper ion import
methanobactin biosynthesis cassette protein MbnCmbnCYESTIGR04160 (HMM): methanobactin biosynthesis cassette protein MbnCGO:0015677: copper ion import

Parent Properties
AccessionName
GenProp0077natural products biosynthesis


Sibling Properties
AccessionName
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0810bacteriocin system, linocin M18 group
GenProp0823violacein biosynthesis
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE