Genome Property Definition Page
Accession | GenProp0963 | |
Name | O2(Ec) antigen biosynthesis | |
Type | METAPATH | |
Description | The O2 antigen is a branched pentasaccharide observed in strains 1.2741 and 9.1649. It consists of the repeating unit [->3)a-L-Rha-((2<-1)-a-D-Fuc3NAc)-(1->2)-a-L-Rha-(1->3)-b-L-Rha-(1->4)-b-D-GlcNAc-(1->]. Genes for the biosynthesis of Rhamnose and 3-acylamino-fucose (Fuc3NAc), both of which arise from the same intermediate, 4,6-dideoxy-4-oxo-dTDP-D-glucose, are found within the cluster. | |
Parent Property | GenProp0913: E. coli O-antigen monomer biosynthesis clusters | |
Literature References |
|
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
source of 3-acetamidofucose | Fuc3NAc | YES | GenProp0964 (GENPROP): dTDP-3-acetamidofucose (dTDP-Fuc3NAc) biosynthesis from dTDP-3-aminofucose | |
b-L-Rha-(1->4)-b-D-GlcNAc transferase | GTR-1 | YES | 2770 (RULE_BASE) | |
a-L-Rha-(1->2)-a-L-Rha, ->3)-b-L-Rha transferase | GTR-2,3 | YES | 2769 (RULE_BASE) | |
a-D-Fuc3NAc-(1->2)-a-L-Rha transferase | GTR-4 | YES | 2768 (RULE_BASE) | |
source of Rhamnose | Rha | YES | GenProp0183 (GENPROP): dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose | |
regulatory protein GalF | galF | YES | TIGR01105 (HMM): regulatory protein GalF | |
clustered gnd enzyme | gnd | NO | TIGR00873 (HMM-CLUST): 6-phosphogluconate dehydrogenase (decarboxylating) | |
O2-antigen specific transporter (flippase) | wzx2 | YES | 2767 (RULE_BASE) | |
clustered wzy protein | wzy | YES | 2848 (RULE_BASE) | |
O-antigen specific chain length determinant protein wzz | wzz | YES | 2846 (RULE_BASE) |
Parent Properties
Accession | Name |
---|---|
GenProp0913 | E. coli O-antigen monomer biosynthesis clusters |
Sibling Properties
Accession | Name |
---|---|
GenProp0932 | O104(Ec) antigen biosynthesis |
GenProp0947 | O55(Ec) antigen biosynthesis |
GenProp0949 | O111(Ec) antigen biosynthesis |
GenProp0953 | O103(Ec) antigen biosynthesis |
GenProp1014 | O5(Ec) antigen biosynthesis |
GenProp1018 | O8(Ec) antigen biosynthesis |
GenProp1042 | O128(Ec) antigen biosynthesis |