Genome Property Definition Page
| Accession | GenProp1030 | |
| Name | O88(Ec) antigen biosynthesis | |
| Type | METAPATH | |
| Description | The E. coli O88 antigen monomer is a branched tetrasaccharide with the structure: [->4)aDMan{(3<-1)aL6dTal}(1->3)aDMan(1->3)bDGlcNAc(1->] [1]. There is currently no experimental literature on the genes involved in the biosynthesis. The expectation, however is that there should be three distinct glycosytransferases and genes for the biosynthesis of GDP-D-mannose and a nucleotide-activated L-6-deoxy-talose. | |
| JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides | |
| Literature References |
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| Web References | ECODAB_O88 |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| source of dTDP-6-deoxy-L-talose | 6dLTal | YES | GenProp1033 (GENPROP): dTDP-6-deoxy-L-talose biosynthesis from dTDP-4-dehydro-L-rhamnose | |
| O88(Ec)-associated glycosyltransferase GT-1 | GT-1 | YES | ||
| O88(Ec)-associated glycosyltransferase GT-2 | GT-2 | YES | ||
| O88(Ec)-associated glycosyltransferase GT-3 | GT-3 | YES | ||
| source of GDP-D-mannose | dMan | YES | GenProp1017 (GENPROP): GDP-D-mannose biosynthesis from b-D-fructose-6-phosphate | |
| O88(Ec)-antigen specific transporter (flippase) wzx | wzx88 | YES | ||
| O88(Ec)-antigen specific polymerase wzy | wzy88 | YES |