Genome Property Definition Page

NameO88(Ec) antigen biosynthesis
DescriptionThe E. coli O88 antigen monomer is a branched tetrasaccharide with the structure: [->4)aDMan{(3<-1)aL6dTal}(1->3)aDMan(1->3)bDGlcNAc(1->] [1]. There is currently no experimental literature on the genes involved in the biosynthesis. The expectation, however is that there should be three distinct glycosytransferases and genes for the biosynthesis of GDP-D-mannose and a nucleotide-activated L-6-deoxy-talose.
JCVI RoleBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Literature References
[ 1 ]Torgov VI, Shashkov AS, Kochanowski H, Jann B, Jann K  NMR analysis of the structure of the O88 polysaccharide (O88 antigen) of Escherichia coli O88:K-:H25.  Carbohydr Res. 1996 Mar 22;283:223-7.  PMID 8901274
Web ReferencesECODAB_O88

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
source of dTDP-6-deoxy-L-talose6dLTalYESGenProp1033 (GENPROP): dTDP-6-deoxy-L-talose biosynthesis from dTDP-4-dehydro-L-rhamnose
O88(Ec)-associated glycosyltransferase GT-1GT-1YES
O88(Ec)-associated glycosyltransferase GT-2GT-2YES
O88(Ec)-associated glycosyltransferase GT-3GT-3YES
source of GDP-D-mannosedManYESGenProp1017 (GENPROP): GDP-D-mannose biosynthesis from b-D-fructose-6-phosphate
O88(Ec)-antigen specific transporter (flippase) wzxwzx88YES
O88(Ec)-antigen specific polymerase wzywzy88YES