Genome Property Definition Page

AccessionGenProp1060
NametRNA N6-threonylcarbamoyladenosine modification
TypeSYSTEM
DescriptionE. coli genes ygjD, yeaZ, yrdC (rimN) and yjeE encode proteins involved in a universal tRNA modification, N6-threonylcarbamoyladenosine.
JCVI RoletRNA and rRNA base modification
Parent PropertyGenProp0819: RNA metabolism
Literature References
[ 1 ]Hashimoto C, Sakaguchi K, Taniguchi Y, Honda H, Oshima T, Ogasawara N, Kato J  Effects on transcription of mutations in ygjD, yeaZ, and yjeE genes, which are involved in a universal tRNA modification in Escherichia coli.  J Bacteriol. 2011 Nov;193(21):6075-9.  PMID 21873492
[ 2 ]Deutsch C, El Yacoubi B, de Crecy-Lagard V, Iwata-Reuyl D  Biosynthesis of Threonylcarbamoyl Adenosine (t6A), a Universal tRNA Nucleoside.  J Biol Chem. 2012 Apr 20;287(17):13666-73.  PMID 22378793
Gene Ontology TermGO:0006400: tRNA modification (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
YeaZ proteinN6_YeaZYESTIGR03725 (HMM): tRNA threonylcarbamoyl adenosine modification protein YeaZGO:0006400: tRNA modification
YgjD proteinN6_YgjDYESTIGR03723 (HMM): tRNA threonylcarbamoyl adenosine modification protein YgjDGO:0006400: tRNA modification
YjeE proteinN6_YjeEYESTIGR00150 (HMM): tRNA threonylcarbamoyl adenosine modification protein YjeEGO:0006400: tRNA modification
YrdC proteinN6_YrdCYESTIGR00057 (HMM): tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC familyGO:0006400: tRNA modification

Parent Properties
AccessionName
GenProp0819RNA metabolism


Sibling Properties
AccessionName
GenProp0258tRNA aminoacylation
GenProp0262RNA polymerase, bacterial
GenProp04826S RNA (eubacterial RNA polymerase regulator)
GenProp0677queuosine (Q-tRNA) biosynthesis from preQ0
GenProp0692selenouridine-containing tRNA
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0898RNA ligase/unknown protein pair
GenProp0948RNA repair, Hen1/Pnkp system
GenProp1077tRNA(Pro) cmo5UGG modification