Genome Property Definition Page
| Accession | GenProp1074 | |
| Name | type V secretion | |
| Type | SYSTEM | |
| Description | Type V secretion systems (T5SS) are most commonly the classical monomeric autotransporters (type Va), in which a C-terminal outer membrane (OM) beta barrel domain functions as a translocator through the OM for an N-terminal passenger domain of the same polypeptide chain. Many type Va autotransporters cleave autocatalytically to release the passenger domain. In type Vb systems, called two-partner secretion systems, the passenger and translocator domains are in separate polypeptides. Additional variant forms Vc, Vd, and Ve have also been described. A special type of signal peptide (PF13018) tethers the nascent polypeptide chain to the Sec apparatus in some autotransporters to allow proper completion of C-terminal domain folding in the OM. | |
| JCVI Role | Protein and peptide secretion and trafficking | |
| Parent Property | GenProp0179: protein transport | |
| Literature References |
| |
| Gene Ontology Term | GO:0046819: protein secretion by the type V secretion system (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| type V secretion system signal peptide | T5SSsig | NO | PF13018 (HMM): type V secretion system signal peptide | GO:0046819: protein secretion by the type V secretion system |
| T5SS outer membrane translocator | autotran | YES | TIGR01414 (HMM): outer membrane autotransporter barrel domain PF03865 (HMM): hemolysin secretion/activation protein, ShlB/FhaC/HecB family | GO:0046819: protein secretion by the type V secretion system GO:0046819: protein secretion by the type V secretion system |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0179 | protein transport |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0052 | type III secretion |
| GenProp0053 | type II secretion |
| GenProp0054 | type IV secretion |
| GenProp0059 | type I secretion |
| GenProp0127 | Tat (Sec-independent) protein export |
| GenProp0205 | signal recognition system, bacterial |
| GenProp0207 | lipoprotein localization system lolABCDE |
| GenProp0209 | Sec system preprotein translocase |
| GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
| GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
| GenProp0626 | protein sorting system, sortase type, LPXTG/SrtA class |
| GenProp0664 | protein sorting system, sortase type, SrtB class |
| GenProp0669 | protein sorting system, putative, exosortase G class |
| GenProp0735 | type VI secretion |
| GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
| GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
| GenProp0845 | protein sorting system, KxYKxGKxW class |
| GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
| GenProp0904 | type VII secretion, Actinobacteria form |
| GenProp0905 | type VII secretion, Firmicutes form |
| GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
| GenProp0957 | protein sorting system, SipW class |
| GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
| GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
| GenProp0980 | protein sorting system, putative, exosortase F class |
| GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
| GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
| GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
| GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
| GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
| GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
| GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
| GenProp0999 | Por secretion system |
| GenProp1005 | protein sorting system, putative, exosortase J class |
| GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
| GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |