Genome Property Definition Page

AccessionGenProp1076
Namecholine TMA-lyase system
TypeSYSTEM
DescriptionThis system has two key enzymes for choline utilization. CutD is a radical SAM enzyme that performs a post-translational modification to activate the glycyl radical enzyme CutC. Bioinformatic, mutational, and chemical studies suggest CutC acts as a choline-TMA lyase, cleaving a C-N bond to turn choline into trimethylamine and acetaldehyde.
JCVI RoleAmino acids and amines
Parent PropertyGenProp0142: catabolism
Literature References
[ 1 ]Craciun S, Balskus EP  Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.  Proc Natl Acad Sci U S A. 2012 Nov 14.  PMID 23151509
Gene Ontology TermGO:0042426: choline catabolic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
choline TMA-lyasecutCYESTIGR04394 (HMM): choline trimethylamine-lyaseGO:0042426: choline catabolic process
choline TMA-lyase-activating enzymecutDYESTIGR04395 (HMM): choline TMA-lyase-activating enzymeGO:0042426: choline catabolic process

Parent Properties
AccessionName
GenProp0142catabolism


Sibling Properties
AccessionName
GenProp0055polyhydroxyalkanoic acids
GenProp0141galactose-6-phosphate degradation via tagatose-6-phosphate
GenProp0156cyanophycin-like storage polymers
GenProp0168glycogen system
GenProp0210phenylacetic acid catabolism
GenProp02314-hydroxyphenylacetate degradation
GenProp0233GABA utilization
GenProp02382-aminoethylphosphonate catabolism to acetaldehyde
GenProp0239propionyl-CoA catabolism
GenProp0241phosphonate catabolism
GenProp0271trehalose utilization
GenProp0272pyruvate fermentation to acetoin
GenProp0273protocatechuate degradation to beta-ketoadipate
GenProp0283beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA
GenProp0294ethanolamine catabolism to acetaldehyde
GenProp0457rhamnose catabolism
GenProp0458fucose catabolism
GenProp0461utilization of deoxynucleosides
GenProp0653ectoine catabolism
GenProp0674malonate decarboxylase
GenProp0686allantoin catabolism to glyoxalate and urea
GenProp0687allantoin catabolism to oxamate and carbamoyl-phosphate
GenProp0688urate catabolism to allantoin
GenProp0691glycolysis
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp0700purine catabolism via urate, xanthine and allantoin
GenProp0702benzoyl-CoA reductase
GenProp07034-hydroxybenzoyl-CoA reductase
GenProp0706cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway
GenProp0708catechol meta-cleavage pathway
GenProp0709benzoate catabolism BoxABC pathway
GenProp0711catechol ortho-cleavage upper pathway
GenProp0714galactarate utilization via tartronate semi-aldehyde
GenProp0715galactarate utilization via 2-oxoglutarate semialdehyde
GenProp0716glucarate utilization via tartronate semi-aldehyde
GenProp0717glucarate utilization via 2-oxoglutarate semialdehyde
GenProp0718oxalate degradation
GenProp0734amino acid catabolism
GenProp0749choline sulfate utilization
GenProp0760putrescine degradation to GABA via gamma-glutamylation
GenProp0763nicotinate fermentation to pyruvate and propionate
GenProp0813pyrimidine utilization operon, RutABCDEFGR
GenProp0902quinohemoprotein amine dehydrogenase
GenProp1071myo-inositol catabolism
GenProp1072cyanase system