Genome Property Definition Page

Accession

GenProp1079

Name

Lpt lipopolysaccharide export transenvelope protein complex

Type

SYSTEM

Description

Lipopolysaccharide transport(Lpt) as it occurs in E. coli requires a complex with seven essential genes. LptBCFG spans the inner membrane, with LptBFG being an ABC transporter. LptA is periplasmic, and LptDE is in the outer membrane.

JCVI Role

Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides

Literature References

[ 1 ]Villa R, Martorana AM, Okuda S, Gourlay LJ, Nardini M, Sperandeo P, Deho G, Bolognesi M, Kahne D, Polissi A The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains. J Bacteriol. 2013 Jan 4. PMID 23292770
[ 2 ]Bos MP, Tommassen J The LptD chaperone LptE is not directly involved in lipopolysaccharide transport in Neisseria meningitidis. J Biol Chem. 2011 Aug 19;286(33):28688-96. PMID 21705335

Components

Step Name	Step Num	Required	Evidence (Method)
LPS transport periplasmic protein LptA	lptA	YES	TIGR03002 (HMM): lipopolysaccharide transport periplasmic protein LptA
LPS export ABC transporter ATP-binding protein	lptB	YES	TIGR04406 (HMM):
lipopolysaccharide export protein LptC	lptC	YES	PF06835 (HMM): Lipopolysaccharide-assembly, LptC-related TIGR04409 (HMM):
LPS assembly OM complex protein LptD	lptD	YES	PF04453 (HMM): organic solvent tolerance protein
LPS assembly OM complex protein LptE	lptE	YES	PF04390 (HMM): rare lipoprotein B family
LPS export ABC permease LptF	lptF	YES	TIGR04407 (HMM):
LPS export ABC permease LptG	lptG	YES	TIGR04408 (HMM):