Genome Property Definition Page

Nameprotein O-heptosyltransferase with autotransporter target
DescriptionAah and TibC are protein O-heptosyltransferases that glycosylate certain repeat-rich proteins at multiple sites. Their targets are the autotransporter (T5SS) proteins AIDA (autotransporter adhesin involved in diffuse adherence) and TibA, respectively. Similar tandem gene pairs occur in Burkholderia vietnamiensis G4, Granulibacter bethesdensis CGDNIH1, Cronobacter sakazakii ATCC BAA-894, and Bradyrhizobium sp. ORS278. In Burkholderia mallei, the heptosyltransferase occurs next to BimA, an autotransporter virulence factor involved in actin-based motility, suggesting glycosylation, although BimA lacks the repeat structure recognized by model TIGR04415.
Parent PropertyGenProp0075: protein modification, prosthetic groups and cofactors
Literature References
[ 1 ]Otzen D  N for AsN - O for strOcture? A strand-loop-strand motif for prokaryotic O-glycosylation.  Mol Microbiol. 2012 Mar;83(5):879-83.  PMID 22221153

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
autotransporter strand-loop-strand O-heptosyltransferaseO_heptYESTIGR04414 (HMM): autotransporter strand-loop-strand O-heptosyltransferase
autotransporter strand-loop-strand repeatO_targYESTIGR04415 (HMM-CLUST): autotransporter passenger strand-loop-strand repeat

Parent Properties
GenProp0075protein modification, prosthetic groups and cofactors

Sibling Properties
GenProp0002coenzyme F420 utilization
GenProp0016selenocysteine system
GenProp0061lipoprotein system lgt/lsp/lnt
GenProp0127Tat (Sec-independent) protein export
GenProp0284cobalamin-utilizing enzymes
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0726selenium-dependent molybdenum hydroxylase system
GenProp0745lipoyl-protein attachment
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0918anaerobic sulfatase/maturase system
GenProp0923mycothiol system
GenProp0933bacillithiol utilization
GenProp0938glycine radical enzyme system, YjjI/YjjW pair
GenProp0943pyruvate formate-lyase system