Genome Property Definition Page

AccessionGenProp1081
Namereplication restart, PriA/PriB primosome pathway
TypeSYSTEM
DescriptionThe bacterial primosome, as in E. coli, restarts replication at sites away from oriC (where DnaA acts), the normal origin of replication. PriB is a member of the larger family of single-stranded DNA-binding (ssb) protein. It is nearly always located between the genes for ribosomal protein S6 and S18, but appears to be only a subset of such ssb family members. The ssb member from the same location in most genomes is longer, and more closely related to a paralog of E. coli PriB than to PriB itself.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0116: DNA metabolism
GenProp0116: DNA metabolism
GenProp0116: DNA metabolism
Literature References
[ 1 ]Lopper M, Boonsombat R, Sandler SJ, Keck JL  A hand-off mechanism for primosome assembly in replication restart.  Mol Cell. 2007 Jun 22;26(6):781-93.  PMID 17588514
[ 2 ]Szymanski MR, Jezewska MJ, Bujalowski W  Binding of two PriA-PriB complexes to the primosome assembly site initiates primosome formation.  J Mol Biol. 2011 Aug 5;411(1):123-42.  PMID 21641914
[ 1 ]Lopper M, Boonsombat R, Sandler SJ, Keck JL  A hand-off mechanism for primosome assembly in replication restart.  Mol Cell. 2007 Jun 22;26(6):781-93.  PMID 17588514
[ 2 ]Szymanski MR, Jezewska MJ, Bujalowski W  Binding of two PriA-PriB complexes to the primosome assembly site initiates primosome formation.  J Mol Biol. 2011 Aug 5;411(1):123-42.  PMID 21641914
[ 1 ]Lopper M, Boonsombat R, Sandler SJ, Keck JL  A hand-off mechanism for primosome assembly in replication restart.  Mol Cell. 2007 Jun 22;26(6):781-93.  PMID 17588514
[ 2 ]Szymanski MR, Jezewska MJ, Bujalowski W  Binding of two PriA-PriB complexes to the primosome assembly site initiates primosome formation.  J Mol Biol. 2011 Aug 5;411(1):123-42.  PMID 21641914
Gene Ontology TermGO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)
GO:0006269: DNA replication, synthesis of RNA primer (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
primosomal protein DnaTDnaTNO
primosomal protein DnaTDnaTNO
primosomal protein DnaTDnaTNO
primosome helicase PriAPriAYESTIGR00595 (HMM): primosomal protein N'
TIGR00595 (HMM): primosomal protein N'
GO:0006269: DNA replication, synthesis of RNA primer
GO:0006269: DNA replication, synthesis of RNA primer
primosome helicase PriAPriAYESTIGR00595 (HMM): primosomal protein N'
TIGR00595 (HMM): primosomal protein N'
GO:0006269: DNA replication, synthesis of RNA primer
GO:0006269: DNA replication, synthesis of RNA primer
primosome helicase PriAPriAYESTIGR00595 (HMM): primosomal protein N'
TIGR00595 (HMM): primosomal protein N'
GO:0006269: DNA replication, synthesis of RNA primer
GO:0006269: DNA replication, synthesis of RNA primer
primosome protein PriBPriBYESTIGR04418 (HMM): primosomal replication protein PriB
TIGR04418 (HMM): primosomal replication protein PriB
GO:0006269: DNA replication, synthesis of RNA primer
GO:0006269: DNA replication, synthesis of RNA primer
primosome protein PriBPriBYESTIGR04418 (HMM): primosomal replication protein PriB
TIGR04418 (HMM): primosomal replication protein PriB
GO:0006269: DNA replication, synthesis of RNA primer
GO:0006269: DNA replication, synthesis of RNA primer
primosome protein PriBPriBYESTIGR04418 (HMM): primosomal replication protein PriB
TIGR04418 (HMM): primosomal replication protein PriB
GO:0006269: DNA replication, synthesis of RNA primer
GO:0006269: DNA replication, synthesis of RNA primer

Parent Properties
AccessionName
GenProp0116DNA metabolism
GenProp0116DNA metabolism
GenProp0116DNA metabolism


Sibling Properties
AccessionName
GenProp0115DNA repair
GenProp0198ruvABC Holliday junction complex
GenProp0263DNA polymerase III, bacterial
GenProp0455restriction enzyme system, type I
GenProp0487repABC-type alpha-proteobacterial replicon(s)
GenProp0650type II restriction system, Alw26I/Eco31I/Esp3I family
GenProp0701DNA sulfur modification system dnd
GenProp0806replication initiation, bacterial
GenProp0977DNA ligase/helicase system
GenProp1095exodeoxyribonuclease VII