Genome Property Definition Page

Namepyranoside core peptidyl nucleoside antibiotic biosynthesis
DescriptionBlasticidin S and mildiomycin are examples of peptidyl nucleoside antibiotics with a pyranoside core moiety. The two key enzymes to make this moeity are cytosylglucuronate (or hydroxymethylcytosylglucuronate) synthase and cytosylglucuronate decarboxylase. The latter is a radical SAM enzyme.
JCVI RoleToxin production and resistance
Literature References
[ 1 ]Wu J, Li L, Deng Z, Zabriskie TM, He X  Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase.  Chembiochem. 2012 Jul 23;13(11):1613-21. doi: 10.1002/cbic.201200173.  PMID 22753012
[ 2 ]Feng J, Wu J, Dai N, Lin S, Xu HH, Deng Z, He X  Discovery and Characterization of BlsE, a Radical S-Adenosyl-L-methionine Decarboxylase Involved in the Blasticidin S Biosynthetic Pathway.  PLoS One. 2013 Jul 18;8(7):e68545. doi: 10.1371/journal.pone.0068545.  PMID 23874663

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
cytosylglucuronate synthaseMilCYESTIGR04467 (HMM): hydroxymethylcytosylglucuronate/cytosylglucuronate synthase
cytosylglucuronate decarboxylaseMilGYESTIGR04466 (HMM): cytosylglucuronate decarboxylase