Genome Property Definition Page

AccessionGenProp1089
NameB12-dependent trimeric diol/glycerol dehydratase
TypeSYSTEM
DescriptionThis Genome Property describes a trimeric, B12-dependent enzyme in a polyhedral microcompartment, or metabolosome, related to (but distinct from) the RuBisCO-containing carboxysome. Described examples include the propanediol dehydratase PduCDE (Pdu means propane diol utilization) and the glycerol dehydratase (also called PduCDE) of Lactobacillus reuteri. The latter converts glycerol in one step to 3-hydroxypropionaldehyde, also called reuterin, a compound that confers probiotic effects.
Parent PropertyGenProp0070: energy metabolism
Literature References
[ 1 ]Bobik TA, Havemann GD, Busch RJ, Williams DS, Aldrich HC  The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2 includes genes necessary for formation of polyhedral organelles involved in coenzyme B(12)-dependent 1, 2-propanediol degradation.  J Bacteriol. 1999 Oct;181(19):5967-75.  PMID 10498708
[ 2 ]Sriramulu DD, Liang M, Hernandez-Romero D, Raux-Deery E, Lunsdorf H, Parsons JB, Warren MJ, Prentice MB  Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionation.  J Bacteriol. 2008 Jul;190(13):4559-67. doi: 10.1128/JB.01535-07. Epub 2008 May 9  PMID 18469107
[ 3 ]Mori K, Hosokawa Y, Yoshinaga T, Toraya T  Diol dehydratase-reactivating factor is a reactivase--evidence for multiple turnovers and subunit swapping with diol dehydratase.  FEBS J. 2010 Dec;277(23):4931-43. doi: 10.1111/j.1742-4658.2010.07898.x.  PMID 21040475

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
diol/glycerol dehydratase, large subunitPduCYESPF02286 (HMM): dehydratase large subunit
diol/glycerol dehydratase, medium subunitPduDYESPF02288 (HMM): dehydratase medium subunit
diol/glycerol dehydratase, small subunitPduEYESPF02287 (HMM): dehydratase small subunit
diol dehydratase reactivation protein PduGPduGYESTIGR04491 (HMM): diol dehydratase reactivase alpha subunit

Parent Properties
AccessionName
GenProp0070energy metabolism


Sibling Properties
AccessionName
GenProp0011methanogenesis
GenProp0023glyoxylate shunt
GenProp0027photosynthesis
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0298fermentation
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0611aerobic respiration
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0682formate-dependent nitrite reductase, seven-gene type
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0691glycolysis
GenProp0695cytochrome b558/566
GenProp0723hydrogenase, nickel and F420-dependent
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0914hydrogenase, [FeFe]-dependent
GenProp0915hydrogenase, mono-iron type