| Description | This Genome Property describes a trimeric, B12-dependent enzyme in a polyhedral microcompartment, or metabolosome, related to (but distinct from) the RuBisCO-containing carboxysome. Described examples include the propanediol dehydratase PduCDE (Pdu means propane diol utilization) and the glycerol dehydratase (also called PduCDE) of Lactobacillus reuteri. The latter converts glycerol in one step to 3-hydroxypropionaldehyde, also called reuterin, a compound that confers probiotic effects. |
| Literature References | [ 1 ]Bobik TA, Havemann GD, Busch RJ, Williams DS, Aldrich HC The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2 includes genes necessary for formation of polyhedral organelles involved in coenzyme B(12)-dependent 1, 2-propanediol degradation. J Bacteriol. 1999 Oct;181(19):5967-75. PMID 10498708
[ 2 ]Sriramulu DD, Liang M, Hernandez-Romero D, Raux-Deery E, Lunsdorf H, Parsons JB, Warren MJ, Prentice MB Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionation. J Bacteriol. 2008 Jul;190(13):4559-67. doi: 10.1128/JB.01535-07. Epub 2008 May 9 PMID 18469107
[ 3 ]Mori K, Hosokawa Y, Yoshinaga T, Toraya T Diol dehydratase-reactivating factor is a reactivase--evidence for multiple turnovers and subunit swapping with diol dehydratase. FEBS J. 2010 Dec;277(23):4931-43. doi: 10.1111/j.1742-4658.2010.07898.x. PMID 21040475
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