Genome Property Definition Page

AccessionGenProp1096
Namecoenzyme B biosynthesis
TypePATHWAY
DescriptionCoenzyme B is 7-mercaptoheptanoylthreoninephosphate. Coenzyme M and coenzyme B for a heterodisulfide during a key step in methanogenesis. This property is inactive: equivalog-level HMMs to provide evidence for computing this pathway are not yet available.
JCVI RoleOther
Parent PropertyGenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
GenProp0184: cofactor biosynthesis
Literature References
[ 4 ]Graham DE  2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis.  Methods Enzymol. 2011;494:301-26. doi: 10.1016/B978-0-12-385112-3.00015-9.  PMID 21402221
[ 1 ]Howell DM, Harich K, Xu H, White RH  Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.  Biochemistry. 1998 Jul 14;37(28):10108-17.  PMID 9665716
[ 2 ]Howell DM, Graupner M, Xu H, White RH  Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.  J Bacteriol. 2000 Sep;182(17):5013-6.  PMID 10940051
[ 3 ]Drevland RM, Jia Y, Palmer DR, Graham DE  Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.  J Biol Chem. 2008 Oct 24;283(43):28888-96. doi: 10.1074/jbc.M802159200.  PMID 18765671
[ 1 ]Howell DM, Harich K, Xu H, White RH  Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.  Biochemistry. 1998 Jul 14;37(28):10108-17.  PMID 9665716
[ 2 ]Howell DM, Graupner M, Xu H, White RH  Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.  J Bacteriol. 2000 Sep;182(17):5013-6.  PMID 10940051
[ 3 ]Drevland RM, Jia Y, Palmer DR, Graham DE  Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.  J Biol Chem. 2008 Oct 24;283(43):28888-96. doi: 10.1074/jbc.M802159200.  PMID 18765671
[ 4 ]Graham DE  2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis.  Methods Enzymol. 2011;494:301-26. doi: 10.1016/B978-0-12-385112-3.00015-9.  PMID 21402221
[ 1 ]Howell DM, Harich K, Xu H, White RH  Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.  Biochemistry. 1998 Jul 14;37(28):10108-17.  PMID 9665716
[ 2 ]Howell DM, Graupner M, Xu H, White RH  Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.  J Bacteriol. 2000 Sep;182(17):5013-6.  PMID 10940051
[ 3 ]Drevland RM, Jia Y, Palmer DR, Graham DE  Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.  J Biol Chem. 2008 Oct 24;283(43):28888-96. doi: 10.1074/jbc.M802159200.  PMID 18765671
[ 4 ]Graham DE  2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis.  Methods Enzymol. 2011;494:301-26. doi: 10.1016/B978-0-12-385112-3.00015-9.  PMID 21402221
Gene Ontology TermGO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)
GO:0019298: coenzyme B biosynthetic process (biological_process)

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
methanogen homoaconitase, large subunitHACN_lgYES
methanogen homoaconitase, large subunitHACN_lgYES
methanogen homoaconitase, large subunitHACN_lgYES
methanogen homoaconitase, small subunitHACN_smYES
methanogen homoaconitase, small subunitHACN_smYES
methanogen homoaconitase, small subunitHACN_smYES
homoisocitrate dehydrogenaseHICDHYES
homoisocitrate dehydrogenaseHICDHYES
homoisocitrate dehydrogenaseHICDHYES

Parent Properties
AccessionName
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis
GenProp0184cofactor biosynthesis


Sibling Properties
AccessionName
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis