Genome Property Definition Page

Namecoenzyme B biosynthesis
DescriptionCoenzyme B is 7-mercaptoheptanoylthreoninephosphate. Coenzyme M and coenzyme B for a heterodisulfide during a key step in methanogenesis. This property is inactive: equivalog-level HMMs to provide evidence for computing this pathway are not yet available.
JCVI RoleOther
Parent PropertyGenProp0184: cofactor biosynthesis
Literature References
[ 1 ]Howell DM, Harich K, Xu H, White RH  Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.  Biochemistry. 1998 Jul 14;37(28):10108-17.  PMID 9665716
[ 2 ]Howell DM, Graupner M, Xu H, White RH  Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.  J Bacteriol. 2000 Sep;182(17):5013-6.  PMID 10940051
[ 3 ]Drevland RM, Jia Y, Palmer DR, Graham DE  Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.  J Biol Chem. 2008 Oct 24;283(43):28888-96. doi: 10.1074/jbc.M802159200.  PMID 18765671
[ 4 ]Graham DE  2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis.  Methods Enzymol. 2011;494:301-26. doi: 10.1016/B978-0-12-385112-3.00015-9.  PMID 21402221
Gene Ontology TermGO:0019298: coenzyme B biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
methanogen homoaconitase, large subunitHACN_lgYES
methanogen homoaconitase, small subunitHACN_smYES
homoisocitrate dehydrogenaseHICDHYES

Parent Properties
GenProp0184cofactor biosynthesis

Sibling Properties
GenProp0001chorismate biosynthesis via shikimate
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0038tetrahydrofolate biosynthesis from GTP and PABA
GenProp0057NAD(P) biosynthesis from L-aspartate and DHAP
GenProp0112riboflavin, FAD and FMN from GTP and ribulose-5-P
GenProp0124pantothenate biosynthesis from aspartate and 2-oxoisovalerate
GenProp0136ubiquinone biosynthesis from chorismate, aerobic
GenProp0140iron-sulfur cluster assembly systems
GenProp0170coenzyme PQQ biosynthesis
GenProp0171coenzyme A biosynthesis from pantothenate
GenProp0194siroheme biosynthesis from uroporphrinogen-III
GenProp0220uroporhyrinogen III biosynthesis from 5-aminolevulinate
GenProp0221protoporphyrin IX biosynthesis from uroporphyrinogen III
GenProp0222protoheme from protoporphyrin IX
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp02555-aminolevulinate biosynthesis
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis
GenProp0274coenzyme B12 biosynthesis - overview
GenProp0300photosynthetic cofactor biosynthesis
GenProp0466molybdopterin biosynthesis
GenProp0752ergothioneine biosynthesis
GenProp0753mycothiol biosynthesis
GenProp0759para-aminobenzoic acid (PABA) biosynthesis from chorismate
GenProp0791coenzyme F420 biosynthesis
GenProp07927,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) biosynthesis
GenProp0836menaquinone biosynthesis
GenProp0860tryptophan tryptophylquinone modification of methylamine dehydrogenase
GenProp0862pyridoxal phosphate biosynthesis, PdxA/PdxJ pathway
GenProp0863pyridoxal phosphate biosynthesis, Pdx1/Pdx2 pathway
GenProp0891coenzyme M biosynthesis
GenProp0917mycofactocin system
GenProp0927bacillithiol biosynthesis
GenProp1064ovothiol biosynthesis