Genome Property Definition Page

AccessionGenProp1099
Name8-oxoguanine DNA repair
TypeSYSTEM
DescriptionMutM excises 8-oxoguanine (8-oxoG) that has formed in DNA that has not since replicated (meaning it should be paired with C). If replication allows 8-oxoG to mispair with A, MutY excises the A to allow replication repair to replace it with a C. Note that MutT performs a different process, hydrolyzing 8-oxo-dGTP to 8-oxo-dGMP to block its incorporation into DNA in the first place, and therefore does perform DNA repair per se.
JCVI RoleDNA replication, recombination, and repair
Parent PropertyGenProp0115: DNA repair
GenProp0115: DNA repair
Literature References
[ 1 ]Hazra TK, Hill JW, Izumi T, Mitra S  Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.  Prog Nucleic Acid Res Mol Biol. 2001;68:193-205.  PMID 11554297
[ 1 ]Hazra TK, Hill JW, Izumi T, Mitra S  Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.  Prog Nucleic Acid Res Mol Biol. 2001;68:193-205.  PMID 11554297

Components
Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
DNA-formamidopyrimidine glycosylaseMutMYESTIGR00577 (HMM): DNA-formamidopyrimidine glycosylase
DNA-formamidopyrimidine glycosylaseMutMYESTIGR00577 (HMM): DNA-formamidopyrimidine glycosylase
A/G-specific adenine glycosylaseMutYYESTIGR01084 (HMM): A/G-specific adenine glycosylase
A/G-specific adenine glycosylaseMutYYESTIGR01084 (HMM): A/G-specific adenine glycosylase

Parent Properties
AccessionName
GenProp0115DNA repair
GenProp0115DNA repair


Sibling Properties
AccessionName
GenProp0114nucleotide excision repair
GenProp0198ruvABC Holliday junction complex
GenProp0215SOS response
GenProp0216recBCD pathway
GenProp0224nucleotide excision repair, alternative pathway
GenProp0225mismatch repair
GenProp0227excision repair
GenProp0228direct repair
GenProp0491recFOR recombination pathway
GenProp0492nonhomologous end-joining, bacterial type
GenProp0493addAB pathway
GenProp0767very short patch repair