HMM Summary Page: TIGR00014

Functionarsenate reductase (glutaredoxin)
Gene SymbolarsC
Trusted Cutoff106.05
Domain Trusted Cutoff106.05
Noise Cutoff61.55
Domain Noise Cutoff61.55
Isology Typeequivalog
EC Number1.20.4.1
HMM Length114
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0008794: arsenate reductase (glutaredoxin) activity molecular_function
GO:0046685: response to arsenic-containing substance biological_process
AuthorHaft DH, Dodson RJ, Richardson DL
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam PF03960. This clade is almost completely restricted to the Proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate.
ReferencesA2 hmmalign DR Medline; 1704144; RA Rosen, BP RT The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase. RL Res Microbiol 141(3):336-341. SE TIGR GA search with previous arsC model AL hmma on previous arsC model BD build_dir/0016
Genome PropertyGenProp0474: arsenical resistance system (HMM-CLUST)