HMM Summary Page: TIGR00016

Functionacetate kinase
Gene SymbolackA
Trusted Cutoff293.40
Domain Trusted Cutoff293.40
Noise Cutoff146.10
Domain Noise Cutoff146.10
Isology Typeequivalog
EC Number2.7.2.1
HMM Length405
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0006083: acetate metabolic process biological_process
GO:0006113: fermentation biological_process
GO:0008776: acetate kinase activity molecular_function
AuthorRichardson DL
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentAcetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate.
ReferencesDR PROSITE; PDOC00826; RN [1] RM 9484901 RT Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate. RA Hesslinger C, Fairhurst SA, Sawers G. RL Mol Microbiol. 1998 Jan;27(2):477-92. DR HAMAP; MF_00020; 241 of 243
Genome PropertyGenProp0478: acetyl-CoA -- acetate interconversion via acetyl phosphate (HMM)
GenProp0754: acetate production from acetylphosphate (HMM)