HMM Summary Page: TIGR00016

AccessionTIGR00016
NameackA
Functionacetate kinase
Gene SymbolackA
Trusted Cutoff293.40
Domain Trusted Cutoff293.40
Noise Cutoff146.10
Domain Noise Cutoff146.10
Isology Typeequivalog
EC Number2.7.2.1
HMM Length405
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0005737: cytoplasm cellular_component
GO:0005737: cytoplasm cellular_component
GO:0006083: acetate metabolic process biological_process
GO:0006083: acetate metabolic process biological_process
GO:0006083: acetate metabolic process biological_process
GO:0006113: fermentation biological_process
GO:0006113: fermentation biological_process
GO:0006113: fermentation biological_process
GO:0008776: acetate kinase activity molecular_function
GO:0008776: acetate kinase activity molecular_function
GO:0008776: acetate kinase activity molecular_function
AuthorRichardson DL
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentAcetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate.
ReferencesDR PROSITE; PDOC00826; RN [1] RM 9484901 RT Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate. RA Hesslinger C, Fairhurst SA, Sawers G. RL Mol Microbiol. 1998 Jan;27(2):477-92. DR HAMAP; MF_00020; 241 of 243
Genome PropertyGenProp0754: acetate production from acetylphosphate (HMM)
GenProp0478: acetyl-CoA -- acetate interconversion via acetyl phosphate (HMM)
GenProp0754: acetate production from acetylphosphate (HMM)
GenProp0478: acetyl-CoA -- acetate interconversion via acetyl phosphate (HMM)
GenProp0754: acetate production from acetylphosphate (HMM)
GenProp0478: acetyl-CoA -- acetate interconversion via acetyl phosphate (HMM)