|Function||acyl-phosphate glycerol 3-phosphate acyltransferase|
|Domain Trusted Cutoff||137.20|
|Domain Noise Cutoff||62.40|
|Mainrole Category||Fatty acid and phospholipid metabolism|
|Gene Ontology Term||GO:0005886: plasma membrane cellular_component|
| ||GO:0006654: phosphatidic acid biosynthetic process biological_process|
| ||GO:0008374: O-acyltransferase activity molecular_function|
|Entry Date||Apr 20 1999 2:04PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||This HMM represents the full length of acylphosphate:glycerol 3-phosphate acyltransferase, and integral membrane protein about 200 amino acids in length, called PlsY in Streptococcus pneumoniae, YneS in Bacillus subtilis, and YgiH in E. coli. It is found in a single copy in a large number of bacteria, including the Mycoplasmas but not Mycobacteria or spirochetes, for example. Its partner is PlsX (see TIGR00182), and the pair can replace PlsB for synthesizing 1-acylglycerol-3-phosphate.|
RT Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase.
RA Lu YJ, Zhang F, Grimes KD, Lee RE, Rock CO
RL J Biol Chem. 2007 Apr 13;282(15):11339-46. Epub 2007 Feb 16.
RT Involvement of the YneS/YgiH and PlsX proteins in phospholipid biosynthesis in both Bacillus subtilis and Escherichia coli.
RA Yoshimura M, Oshima T, Ogasawara N
RL BMC Microbiol. 2007 Jul 24;7:69.
DR InterPro; IPR003811; DUF205
DR PFAM; PF02660; DUF205
DR HAMAP; MF_01043; 351 of 377|
|Genome Property||GenProp0837: 1-acylglycerol-3-phosphate biosynthesis, PlsX/Y pathway (HMM)|
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