HMM Summary Page: TIGR00026

Functiondeazaflavin-dependent oxidoreductase, nitroreductase family
Trusted Cutoff46.35
Domain Trusted Cutoff46.35
Noise Cutoff38.15
Domain Noise Cutoff38.15
Isology Typesubfamily
HMM Length111
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0070967: coenzyme F420 binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedMar 7 2012 12:54PM
CommentThis model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase.
ReferencesSE TIGR DR PFAM; PF04075; DUF385 DR INTERPRO; IPR004378 RN [1] RM PMID:19039139 RT PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. RA Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE 3rd RL Science. 2008 Nov 28;322(5906):1392-5.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)