HMM Summary Page: TIGR00043

Functionprobable rRNA maturation factor YbeY
Gene SymbolybeY
Trusted Cutoff42.05
Domain Trusted Cutoff42.05
Noise Cutoff38.05
Domain Noise Cutoff38.05
Isology Typeequivalog
HMM Length111
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0008150: biological_process biological_process
GO:0046872: metal ion binding molecular_function
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedAug 13 2012 9:51AM
CommentThis metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect.
ReferencesDR HAMAP; MF_00009; 511 of 518 RN [1] RM PMID:20807199 RT Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing. RA Davies BW, Kohrer C, Jacob AI, Simmons LA, Zhu J, Aleman LM, Rajbhandary UL, Walker GC RL Mol Microbiol. 2010 Oct;78(2):506-18. RN [2] RM PMID:16511207 RT The ybeY protein from Escherichia coli is a metalloprotein. RA Zhan C, Fedorov EV, Shi W, Ramagopal UA, Thirumuruhan R, Manjasetty BA, Almo SC, Fiser A, Chance MR, Fedorov AA RL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):959-63. Epub 2005 Oct 20.
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)