Accession | TIGR00079 |
Name | pept_deformyl |
Function | peptide deformylase |
Gene Symbol | def |
Trusted Cutoff | 103.95 |
Domain Trusted Cutoff | 103.95 |
Noise Cutoff | 74.15 |
Domain Noise Cutoff | 74.15 |
Isology Type | equivalog |
EC Number | 3.5.1.88 |
HMM Length | 161 |
Mainrole Category | Protein fate |
Subrole Category | Protein modification and repair |
Gene Ontology Term | GO:0006464: protein modification process biological_process |
| GO:0042586: peptide deformylase activity molecular_function |
Author | Haft DH |
Entry Date | Apr 20 1999 2:09PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Peptide deformylase (EC 3.5.1.88), also called polypeptide deformylase, is a metalloenzyme that uses water to release formate from the N-terminal formyl-L-methionine of bacterial and chloroplast peptides. This enzyme should not be confused with formylmethionine deformylase (EC 3.5.1.31) which is active on free N-formyl methionine and has been reported from rat intestine. |
References | RM 97272005
RT Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.
RA Meinnel T, Lazennec C, Villoing S, Blanquet S
RL J Mol Biol 1997 Apr 4;267(3):749-61
SE TIGR
AL clustalw
DR HAMAP; MF_00163; 323 of 332 |