HMM Summary Page: TIGR00091

FunctiontRNA (guanine-N(7)-)-methyltransferase
Gene SymboltrmB
Trusted Cutoff112.65
Domain Trusted Cutoff112.65
Noise Cutoff82.65
Domain Noise Cutoff82.65
Isology Typeequivalog
EC Number2.1.1.33
HMM Length194
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0006400: tRNA modification biological_process
GO:0008176: tRNA (guanine-N7-)-methyltransferase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis predicted S-adenosylmethionine-dependent methyltransferase is found in a single copy in most Bacteria. It is also found, with a short amino-terminal extension in eukaryotes. Its function is unknown. In E. coli, this protein flanks the DNA repair protein MutY, also called micA.
ReferencesSE TIGR RN [1] RM 12403464 RT Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RA Alexandrov A, Martzen MR, Phizicky EM. RL RNA. 2002 Oct;8(10):1253-66. RN [2] RM 12730187 RT The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase. RA De Bie LG, Roovers M, Oudjama Y, Wattiez R, Tricot C, Stalon V, Droogmans L, Bujnicki JM. RL J Bacteriol. 2003 May;185(10):3238-43. DR HAMAP; MF_01057; 346 of 404