| Accession | TIGR00097 |
| Name | HMP-P_kinase |
| Function | phosphomethylpyrimidine kinase |
| Gene Symbol | thiD |
| Trusted Cutoff | 204.95 |
| Domain Trusted Cutoff | 204.95 |
| Noise Cutoff | 79.35 |
| Domain Noise Cutoff | 79.35 |
| Isology Type | equivalog_domain |
| EC Number | 2.7.4.7 |
| HMM Length | 254 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Thiamine |
| Gene Ontology Term | GO:0008972: phosphomethylpyrimidine kinase activity molecular_function |
| | GO:0009228: thiamine biosynthetic process biological_process |
| Author | Haft DH, Richardson DL, Anolik RT |
| Entry Date | Apr 20 1999 2:03PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents phosphomethylpyrimidine kinase, the ThiD protein of thiamine biosynthesis. The protein is commonly observed within operons containing other thiamine biosynthesis genes. Numerous examples are fusion proteins with other thiamine-biosynthetic domains. Saccaromyces has three recent paralogs, two of which are isofunctional and score above the trusted cutoff. The third shows a longer branch length in a phylogenetic tree and scores below the trusted cutoff, as do putative second copies in a number of species. |
| References | A2 hmmalign
SE TIGR
GA hmmsw
AL msa
BD build_dir/0037 |
| Genome Property | GenProp0253: thiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide (HMM) |
