HMM Summary Page: TIGR00113

FunctionS-adenosylmethionine:tRNA ribosyltransferase-isomerase
Gene SymbolqueA
Trusted Cutoff267.45
Domain Trusted Cutoff267.45
Noise Cutoff158.00
Domain Noise Cutoff158.00
Isology Typeequivalog
EC Number2.4.99.17
HMM Length345
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0006400: tRNA modification biological_process
GO:0008616: queuosine biosynthetic process biological_process
GO:0051075: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity molecular_function
AuthorAnolik RT, Richardson DL
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the enzyme for S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA). QueA synthesizes Queuosine which is usually in the first position of the anticodon of tRNAs specific for asparagine, aspartate, histidine, and tyrosine.
ReferencesDR ECOCYC; EG10812; DR InterPro; IPR003699; Queuosine_synth DR PFAM; PF02547; Queuosine_synth RA Slany RK, Bosl M, Crain PF, Kersten H. RT A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine. RL Biochemistry 32:7811-7817. SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00113; 367 of 372
Genome PropertyGenProp0677: queuosine (Q-tRNA) biosynthesis from preQ0 (HMM)