HMM Summary Page: TIGR00114

Function6,7-dimethyl-8-ribityllumazine synthase
Gene SymbolribH
Trusted Cutoff84.60
Domain Trusted Cutoff84.60
Noise Cutoff77.65
Domain Noise Cutoff77.65
Isology Typeequivalog
EC Number2.5.1.78
HMM Length138
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryRiboflavin, FMN, and FAD
Gene Ontology TermGO:0000906: 6,7-dimethyl-8-ribityllumazine synthase activity molecular_function
GO:0009231: riboflavin biosynthetic process biological_process
GO:0009349: riboflavin synthase complex cellular_component
AuthorAnolik RT, Richardson DL, Selengut J
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the cyclo-ligation of 3,4-dihydroxy-2-butanone-4-P and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 6,7-dimethyl-8-ribityllumazine, the immediate precursor of riboflavin. Sometimes referred to as riboflavin synthase, beta subunit, this should not be confused with the alpha subunit which carries out the subsequent reaction. Archaeal members of this family are considered putative, although included in the seed and scoring above the trusted cutoff.
ReferencesDR ECOCYC; EG11322; RIBH. DR PF00885; DMRL_synthase HMM; SE TIGR GA hmmls AL clustalw RM 96007536 DR HAMAP; MF_00178; 387 of 402
Genome PropertyGenProp0112: riboflavin, FAD and FMN from GTP and ribulose-5-P (HMM)