| Accession | TIGR00121 |
| Name | birA_ligase |
| Function | biotin--[acetyl-CoA-carboxylase] ligase |
| Trusted Cutoff | 83.10 |
| Domain Trusted Cutoff | 83.10 |
| Noise Cutoff | 76.45 |
| Domain Noise Cutoff | 76.45 |
| Isology Type | equivalog_domain |
| EC Number | 6.3.4.15 |
| HMM Length | 235 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein modification and repair |
| Gene Ontology Term | GO:0004077: biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function |
| | GO:0006464: protein modification process biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents the biotin--acetyl-CoA-carboxylase ligase region of biotin--acetyl-CoA-carboxylase ligase. In Escherichia coli and some other species, this enzyme is part of a bifunction protein BirA that includes a small, N-terminal biotin operon repressor domain. Proteins identified by this model should not be called bifunctional unless they are also identified by birA_repr_reg (TIGR00122).
The protein name suggests that this enzyme transfers biotin only to acetyl-CoA-carboxylase but it also transfers the biotin moiety to other proteins. The apparent orthologs among the eukaryotes are larger proteins that contain a single copy of this domain. |
| References | RM 3536662
RT DNA-binding and enzymatic domains of the bifunctional biotin operon repressor (BirA) of Escherichia coli.
RA Buoncristiani MR, Howard PK, Otsuka AJ
RL Gene 1986;44(2-3):255-61
SE TIGR |
| Genome Property | GenProp0036: biotin biosynthesis (HMM) |
