HMM Summary Page: TIGR00138

AccessionTIGR00138
NamersmG_gidB
Function16S rRNA (guanine(527)-N(7))-methyltransferase RsmG
Gene SymbolrsmG
Trusted Cutoff99.50
Domain Trusted Cutoff99.50
Noise Cutoff75.90
Domain Noise Cutoff75.90
Isology Typeequivalog
EC Number2.1.1.170
HMM Length183
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0005575: cellular_component cellular_component
GO:0008168: methyltransferase activity molecular_function
GO:0031167: rRNA methylation biological_process
GO:0046118: 7-methylguanosine biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentRsmG was previously called GidB (glucose-inhibited division protein B). It is present and a single copy in nearly all complete eubacterial genomes. It is missing only from some obligate intracellular species of various lineages (Chlamydiae, Ehrlichia, Wolbachia, Anaplasma, Buchnera, etc.). RsmG shows a methytransferase fold in its the crystal structure, and acts as a 7-methylguanosine (m(7)G) methyltransferase, apparently specific to 16S rRNA.
ReferencesRN [1] RM PMID:17238915 RT Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. RA Okamoto S, Tamaru A, Nakajima C, Nishimura K, Tanaka Y, Tokuyama S, Suzuki Y, Ochi K RN [2] RM 12001236 RT Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold. RA Romanowski MJ, Bonanno JB, Burley SK. RL Proteins. 2002 Jun 1;47(4):563-7. DR HAMAP; MF_00074; 519 of 539