HMM Summary Page: TIGR00143

Functioncarbamoyltransferase HypF
Gene SymbolhypF
Trusted Cutoff466.10
Domain Trusted Cutoff466.10
Noise Cutoff359.80
Domain Noise Cutoff359.80
Isology Typeequivalog
HMM Length741
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0003998: acylphosphatase activity molecular_function
GO:0006464: protein modification process biological_process
AuthorHaft DH, Richardson DL
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentA previously described regulatory effect of HypF mutatation is attributable to loss of activity of a regulatory hydrogenase. A zinc finger-like region CXXCX(18)CXXCX(24)CXXCX(18)CXXC region further supported the regulatory hypothesis. However, more recent work (PUBMED:11375153) shows the direct effect is on the activity of expressed hydrogenases with nickel/iron centers, rather than on expression.
ReferencesRM 11375153 RT Transposon mutagenesis in purple sulfur photosynthetic bacteria: identification of hypF, encoding a protein capable of processing [NiFe] hydrogenases in alpha, beta, and gamma subdivisions of the proteobacteria. RA Fodor B, Rakhely G, Kovacs AT, Kovacs KL. RL Appl Environ Microbiol 2001 Jun;67(6):2476-83
Genome PropertyGenProp0177: nickel-dependent hydrogenase (HMM)