HMM Summary Page: TIGR00160

Functionmethylglyoxal synthase
Gene SymbolmgsA
Trusted Cutoff146.90
Domain Trusted Cutoff146.90
Noise Cutoff71.55
Domain Noise Cutoff71.55
Isology Typeequivalog
EC Number4.2.3.3
HMM Length143
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0006007: glucose catabolic process biological_process
GO:0008929: methylglyoxal synthase activity molecular_function
GO:0019242: methylglyoxal biosynthetic process biological_process
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentMethylglyoxal synthase (MGS) generates methylglyoxal (MG), a toxic metabolite (that may also be a regulatory metabolite and) that is detoxified, prinicipally, through a pathway involving glutathione and glyoxylase I. Totemeyer, et al. (MUID:98149311) propose that, during a loss of control over carbon flux, with accumulation of phosphorylated sugars and depletion of phosphate, as might happen during a rapid shift to a richer medium, MGS aids the cell by converting some dihydroxyacetone phosphate (DHAP) to MG and phosphate. This is therefore an alternative to triosephosphate isomerase and the remainder of the glycolytic pathway for the disposal of DHAP during the stress of a sudden increase in available sugars.
ReferencesDR ECOCYC; EG12307; mgsA; RM 98149311 RT From famine to feast: the role of methylglyoxal production in Escherichia coli. RA Totemeyer S, Booth NA, Nichols WW, Dunbar B, Booth IR RL Mol Microbiol 1998 Feb;27(3):553-62 SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00549; 124 of 127