HMM Summary Page: TIGR00181

AccessionTIGR00181
NamepepF
Functionoligoendopeptidase F
Gene SymbolpepF
Trusted Cutoff490.55
Domain Trusted Cutoff490.55
Noise Cutoff382.10
Domain Noise Cutoff382.10
Isology Typeequivalog
EC Number3.4.24.-
HMM Length591
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0004222: metalloendopeptidase activity molecular_function
GO:0006508: proteolysis biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family represents the oligoendopeptidase F clade of the family of larger M3 or thimet (for thiol-dependent metallopeptidase) oligopeptidase family. Lactococcus lactis PepF hydrolyzed peptides of 7 and 17 amino acids with fairly broad specificity. The homolog of lactococcal PepF in group B Streptococcus was named PepB (PMID:8757883), with the name difference reflecting a difference in species of origin rather activity; substrate profiles were quite similar. Differences in substrate specificity should be expected in other species. The gene is duplicated in Lactococcus lactis on the plasmid that bears it. A shortened second copy is found in Bacillus subtilis.
ReferencesRN [1] RM 7798200 RT Biochemical and genetic characterization of PepF, an oligopeptidase from Lactococcus lactis. RA Monnet V, Nardi M, Chopin A, Chopin MC, Gripon JC. RL J Biol Chem 269, 32070-32076, 1994; RT Biochemical and genetic characterization of PepF, an oligopeptidase from Lactococcus lactis. RN [2] RM 8757883 RT Characterization of PepB, a group B streptococcal oligopeptidase. RA Lin B, Averett WF, Novak J, Chatham WW, Hollingshead SK, Coligan JE, Egan ML, Pritchard DG. RL Infect Immun. 1996 Aug;64(8):3401-6. SE TIGR