| Accession | TIGR00183 |
| Name | prok_nadp_idh |
| Function | isocitrate dehydrogenase, NADP-dependent |
| Gene Symbol | icd |
| Trusted Cutoff | 567.30 |
| Domain Trusted Cutoff | 567.30 |
| Noise Cutoff | 219.05 |
| Domain Noise Cutoff | 219.05 |
| Isology Type | equivalog |
| EC Number | 1.1.1.42 |
| HMM Length | 417 |
| Mainrole Category | Energy metabolism |
| Subrole Category | TCA cycle |
| Gene Ontology Term | GO:0004450: isocitrate dehydrogenase (NADP+) activity molecular_function |
| | GO:0006099: tricarboxylic acid cycle biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site;
Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. |
| References | A2 hmmalign
SE TIGR
GA hmmls
AL clustalw, belvu
BD build_dir/0253 |
| Genome Property | GenProp0033: TCA cycle (HMM) |
