HMM Summary Page: TIGR00185

FunctiontRNA (cytidine(34)-2'-O)-methyltransferase
Gene SymboltrmL
Trusted Cutoff190.60
Domain Trusted Cutoff190.60
Noise Cutoff88.85
Domain Noise Cutoff88.85
Isology Typeequivalog
EC Number2.1.1.207
HMM Length154
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0008173: RNA methyltransferase activity molecular_function
GO:0009451: RNA modification biological_process
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedDec 8 2011 10:04AM
CommentTrmL (previously YibK) is responsible for 2'-O-methylation at tRNA(Leu) position 34.
ReferencesRN [1] RM PMID:20855540 RT YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. RA Benitez-Paez A, Villarroya M, Douthwaite S, Gabaldon T, Armengod ME RL RNA. 2010 Nov;16(11):2131-43. RN [2] RM PMID:12596263 RT Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): a cofactor bound at a site formed by a knot. RA Lim K, Zhang H, Tempczyk A, Krajewski W, Bonander N, Toedt J, Howard A, Eisenstein E, Herzberg O RL Proteins. 2003 Apr 1;51(1):56-67.