HMM Summary Page: TIGR00191

Functionhomoserine kinase
Gene SymbolthrB
Trusted Cutoff168.25
Domain Trusted Cutoff168.25
Noise Cutoff161.15
Domain Noise Cutoff161.15
Isology Typeequivalog
EC Number2.7.1.39
HMM Length304
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0004413: homoserine kinase activity molecular_function
GO:0009088: threonine biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentHomoserine kinase is part of the threonine biosynthetic pathway. Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding. P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054)
ReferencesDR PROSITE; PDOC0054; SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_00384; 228 of 231
Genome PropertyGenProp0159: threonine biosynthesis from aspartate semialdehyde (HMM)