HMM Summary Page: TIGR00198

Functioncatalase/peroxidase HPI
Gene SymbolkatG
Trusted Cutoff770.25
Domain Trusted Cutoff770.25
Noise Cutoff427.70
Domain Noise Cutoff427.70
Isology Typeequivalog
EC Number1.11.1.6
HMM Length716
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0004096: catalase activity molecular_function
GO:0004601: peroxidase activity molecular_function
GO:0006979: response to oxidative stress biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentAs catalase, this enzyme catalyzes the dismutation of two molecules of hydrogen peroxide to dioxygen and two molecules of water. As a peroxidase, it uses hydrogen peroxide to oxidize donor compounds and produce water. KatG from E. coli is a homotetramer with two non-covalently associated iron protoheme IX groups per tetramer, but the ortholog from Synechococcus sp. is a homodimer with one protoheme. Important sites (numbered according to E. coli KatG) include heme ligands His-106 and His-267 and active site Trp-318. Note that the translation PID:g296476 from accession X71420 from Rhodobacter capsulatus B10 contains extensive frameshift differences from the rest of the orthologous family.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_01961; 279 of 304
Genome PropertyGenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM)
GenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM)