HMM Summary Page: TIGR00204

Function1-deoxy-D-xylulose-5-phosphate synthase
Gene Symboldxs
Trusted Cutoff465.95
Domain Trusted Cutoff465.95
Noise Cutoff222.45
Domain Noise Cutoff222.45
Isology Typeequivalog
EC Number2.2.1.7
HMM Length616
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0008615: pyridoxine biosynthetic process biological_process
GO:0008661: 1-deoxy-D-xylulose-5-phosphate synthase activity molecular_function
GO:0009228: thiamine biosynthetic process biological_process
GO:0009240: isopentenyl diphosphate biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentDXP synthase is a thiamine diphosphate-dependent enzyme related to transketolase and the pyruvate dehydrogenase E1-beta subunit. By an acyloin condensation of pyruvate with glyceraldehyde 3-phosphate, it produces 1-deoxy-D-xylulose 5-phosphate, a precursor of thiamine diphosphate (TPP), pyridoxal phosphate, and the isoprenoid building block isopentenyl diphosphate (IPP).
ReferencesDR PROSITE; PDOC00635 RM 98151473 RT Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. RA Lois LM, Campos N, Putra SR, Danielsen K, Rohmer M, Boronat A RL Proc Natl Acad Sci U S A 1998 Mar 3;95(5):2105-10 SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00315; 373 of 379
Genome PropertyGenProp0048: IPP biosynthesis via deoxyxylulose (HMM)