|Function||4-hydroxy-3-methylbut-2-enyl diphosphate reductase|
|Domain Trusted Cutoff||187.85|
|Domain Noise Cutoff||103.60|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Gene Ontology Term||GO:0009240: isopentenyl diphosphate biosynthetic process biological_process|
| ||GO:0015968: stringent response biological_process|
| ||GO:0046677: response to antibiotic biological_process|
| ||GO:0051745: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity molecular_function|
|Author||Loftus BJ, Haft DH|
|Entry Date||Apr 20 1999 2:08PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||The IspH protein (previously designated LytB) has now been recognized as the last enzyme in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Escherichia coli LytB protein had been found to regulate the activity of RelA (guanosine 3',5'-bispyrophosphate synthetase I), which in turn controls the level of a regulatory metabolite. It is involved in penicillin tolerance and the stringent response.|
RM PMID: 11818558
RT Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein.
RA Rohdich F, Hecht S, Gartner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A, Eisenreich W.
RL Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1158-63.
DR ECOCYC; EG11081; lytB;
DR PFAM; PF02401; LYTB
DR InterPro; IPR003451; LytB
DR HAMAP; MF_00191; 291 of 300|
|Genome Property||GenProp0048: IPP biosynthesis via deoxyxylulose (HMM)|
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