|Domain Trusted Cutoff||207.55|
|Domain Noise Cutoff||96.90|
|Mainrole Category||Biosynthesis of cofactors, prosthetic groups, and carriers|
|Subrole Category||Pantothenate and coenzyme A|
|Gene Ontology Term||GO:0003864: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity molecular_function|
| ||GO:0015940: pantothenate biosynthetic process biological_process|
|Entry Date||Apr 20 1999 2:09PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Members of this family are 3-methyl-2-oxobutanoate hydroxymethyltransferase, the first enzyme of the pantothenate biosynthesis pathway. An alternate name is ketopantoate hydroxymethyltransferase.|
RT Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme.
RA Jones CE, Brook JM, Buck D, Abell C, Smith AG.
RL J Bacteriol. 1993 Apr;175(7):2125-30.
DR ECOCYC; EG11675; panB
DR HAMAP; MF_00156; 403 of 405|
|Genome Property||GenProp0124: pantothenate biosynthesis from aspartate and 2-oxoisovalerate (HMM)|
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