HMM Summary Page: TIGR00222

Function3-methyl-2-oxobutanoate hydroxymethyltransferase
Gene SymbolpanB
Trusted Cutoff207.55
Domain Trusted Cutoff207.55
Noise Cutoff96.90
Domain Noise Cutoff96.90
Isology Typeequivalog
EC Number2.1.2.11
HMM Length264
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0003864: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity molecular_function
GO:0015940: pantothenate biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are 3-methyl-2-oxobutanoate hydroxymethyltransferase, the first enzyme of the pantothenate biosynthesis pathway. An alternate name is ketopantoate hydroxymethyltransferase.
ReferencesSE TIGR RN [1] RM 93209959 RT Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme. RA Jones CE, Brook JM, Buck D, Abell C, Smith AG. RL J Bacteriol. 1993 Apr;175(7):2125-30. DR ECOCYC; EG11675; panB DR HAMAP; MF_00156; 403 of 405
Genome PropertyGenProp0124: pantothenate biosynthesis from aspartate and 2-oxoisovalerate (HMM)