HMM Summary Page: TIGR00223

Functionaspartate 1-decarboxylase
Gene SymbolpanD
Trusted Cutoff106.00
Domain Trusted Cutoff106.00
Noise Cutoff83.70
Domain Noise Cutoff83.70
Isology Typeequivalog
EC Number4.1.1.11
HMM Length126
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004068: aspartate 1-decarboxylase activity molecular_function
GO:0015940: pantothenate biosynthetic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are aspartate 1-decarboxylase, the enzyme that makes beta-alanine and C02 from aspartate. Beta-alanine is then used to make the vitamin pantothenate, from which coenzyme A is made. Aspartate 1-decarboxylase is synthesized as a proenzyme, then cleaved to an alpha (C-terminal) and beta (N-terminal) subunit with a pyruvoyl group.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00446; 266 of 276
Genome PropertyGenProp0124: pantothenate biosynthesis from aspartate and 2-oxoisovalerate (HMM)