HMM Summary Page: TIGR00228

Functioncrossover junction endodeoxyribonuclease RuvC
Gene SymbolruvC
Trusted Cutoff100.65
Domain Trusted Cutoff100.65
Noise Cutoff47.50
Domain Noise Cutoff47.50
Isology Typeequivalog
EC Number3.1.22.4
HMM Length156
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006310: DNA recombination biological_process
GO:0008821: crossover junction endodeoxyribonuclease activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentEndonuclease that resolves Holliday junction intermediates in genetic recombination. The active form of the protein is a dimer. Structure studies reveals that the catalytic center, comprised of four acidic residues, lies at the bottom of a cleft that fits a DNA duplex. The model hits a single Synechocystis PCC6803 protein at a score of 30, below the trusted cutoff, that appears orthologous and may act as authentic RuvC.
ReferencesDR ECOCYC; EG10925; ruvC; SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00034; 375 of 393
Genome PropertyGenProp0198: ruvABC Holliday junction complex (HMM)