HMM Summary Page: TIGR00229

FunctionPAS domain S-box protein
Trusted Cutoff22.90
Domain Trusted Cutoff22.90
Noise Cutoff22.10
Domain Noise Cutoff22.10
Isology Typedomain
HMM Length126
Mainrole CategoryRegulatory functions
Subrole CategorySmall molecule interactions
Gene Ontology TermGO:0004871: signal transducer activity molecular_function
GO:0007165: signal transduction biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedJul 18 2011 3:04PM
CommentThe PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator.
ReferencesA2 hmmalign RL Trends Biochem Sci 1997 Sep;22(9):331-333; RM 97446881; RA Zhulin IB, Taylor BL, Dixon R; RT PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox. SE TIGR GA hmmls AL clustalw BD 0296