HMM Summary Page: TIGR00231

Functionsmall GTP-binding protein domain
Trusted Cutoff42.50
Domain Trusted Cutoff42.50
Noise Cutoff35.20
Domain Noise Cutoff35.20
Isology Typedomain
HMM Length164
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0005525: GTP binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentProteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once. This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
ReferencesSE TIGR GA clustalw, seaview, belvu AL clustalw DR HAMAP; MF_00379; 525 of 542