HMM Summary Page: TIGR00240

Functionaspartate carbamoyltransferase, regulatory subunit
Gene SymbolpyrI
Trusted Cutoff148.55
Domain Trusted Cutoff148.55
Noise Cutoff68.10
Domain Noise Cutoff68.10
Isology Typeequivalog
EC Number2.1.3.2
HMM Length150
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPyrimidine ribonucleotide biosynthesis
Gene Ontology TermGO:0004070: aspartate carbamoyltransferase activity molecular_function
GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedMay 25 2011 6:04PM
CommentThe presence of this regulatory subunit allows feedback inhibition by CTP on aspartate carbamoyltransferase, the first step in the synthesis of CTP from aspartate. In many species, this regulatory subunit is not present. In Thermotoga maritima, the catalytic and regulatory subunits are encoded by a fused gene and the regulatory region has enough sequence differences to score below the trusted cutoff.
ReferencesDR EC SE TIGR GA hmmls AL clustalw, belvu DR HAMAP; MF_00002; 109 of 115
Genome PropertyGenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)