|Function||diguanylate cyclase (GGDEF) domain|
|Domain Trusted Cutoff||37.40|
|Domain Noise Cutoff||33.30|
|Mainrole Category||Regulatory functions|
|Subrole Category||Small molecule interactions|
|Gene Ontology Term||GO:0009966: regulation of signal transduction biological_process|
| ||GO:0009975: cyclase activity molecular_function|
|Entry Date||Apr 20 1999 2:03PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity . Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein.|
|References||DR PFAM; PF00990; GGDEF
RT Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity.
RL FEMS Microbiol Lett. 2001 Oct 16;204(1):163-7.
RA Ausmees N, Mayer R, Weinhouse H, Volman G, Amikam D, Benziman M, Lindberg M.
RT Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus.
RL J Bacteriol 1995 Nov;177(21):6223-9
RA Hecht GB, Newton A
RT GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility.
RL Mol Microbiol. 2004 Aug;53(4):1123-34
RA Simm R, Morr M, Kader A, Nimtz M, Romling U
RT Structural basis of activity and allosteric control of diguanylate cyclase.
RA Chan C, Paul R, Samoray D, Amiot NC, Giese B, Jenal U, Schirmer T.
RL Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17084-9|
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