HMM Summary Page: TIGR00274

FunctionN-acetylmuramic acid 6-phosphate etherase
Gene SymbolmurQ
Trusted Cutoff302.00
Domain Trusted Cutoff302.00
Noise Cutoff160.45
Domain Noise Cutoff160.45
Isology Typeequivalog
EC Number4.2.1.126
HMM Length291
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0006040: amino sugar metabolic process biological_process
GO:0009254: peptidoglycan turnover biological_process
GO:0016835: carbon-oxygen lyase activity molecular_function
AuthorDodson RJ, Loftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedDec 12 2011 10:12PM
CommentThis protein, MurQ, is involved in recycling components of the bacterial murein sacculus turned over during cell growth. The cell wall metabolite anhydro-N-acetylmuramic acid (anhMurNAc) is converted by a kinase, AnmK, to MurNAc-phosphate, then converted to N-acetylglucosamine-phosphate by this etherase, called MurQ. This family of proteins is similar to the C-terminal half of a number of vertebrate glucokinase regulator proteins and contains a Prosite pattern which is shared by this group of proteins in a region of local similarity.
ReferencesRN [1] RM PMID: 15983044 RT Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli "etherase". RA Jaeger T, Arsic M, Mayer C. RL J Biol Chem. 2005 Aug 26;280(34):30100-6. RN [2] RM PMID:16452451 RT MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall. RA Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT RL J Bacteriol. 2006 Feb;188(4):1660-2. DR PROSITE; PDOC00979; GCKR AL clustalw, belvu DR HAMAP; MF_00068; 141 of 144
Genome PropertyGenProp0766: anhydro-N-acetylmuramic acid to N-acetylglucosamine-phosphate (HMM)