| Accession | TIGR00287 |
| Name | cas1 |
| Function | CRISPR-associated endonuclease Cas1 |
| Gene Symbol | cas1 |
| Trusted Cutoff | 71.70 |
| Domain Trusted Cutoff | 71.70 |
| Noise Cutoff | 66.00 |
| Domain Noise Cutoff | 66.00 |
| Isology Type | equivalog |
| EC Number | 3.1.-.- |
| HMM Length | 327 |
| Mainrole Category | Mobile and extrachromosomal element functions |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004520: endodeoxyribonuclease activity molecular_function |
| | GO:0043571: maintenance of CRISPR repeat elements biological_process |
| | GO:0046872: metal ion binding molecular_function |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:05PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease. |
| References | DR URL http://www.tigr.org/tigr-scripts/CMR2/genome_property_def.spl?prop=2003
RN [1]
RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes
RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE
RL PLOS Comput. Biol. 1(6), e60-e69, 2005
RN [2]
RM 11952905
RT Identification of genes that are associated with DNA repeats in prokaryotes.
RA Jansen R, Embden JD, Gaastra W, Schouls LM.
RL Mol Microbiol 2002 Mar;43(6):1565-75
RN [3]
RM PMID:19523907
RT Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense.
RA Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA
RL Structure. 2009 Jun 10;17(6):904-12.
DR PFAM; PF01867
DR INTERPRO; IPR002729 |
| Genome Property | GenProp0021: CRISPR region (HMM) |
| | GenProp0313: CRISPR system, Dvulg subtype (HMM-CLUST) |
| | GenProp0315: CRISPR system, Ecoli subtype (HMM-CLUST) |
| | GenProp0317: CRISPR system, Tneap subtype (HMM-CLUST) |
| | GenProp0319: CRISPR system, Apern subtype (Archaea specific) (HMM-CLUST) |
| | GenProp0320: CRISPR system, Hmari subtype (HMM-CLUST) |
| | GenProp0318: CRISPR system, Mtube subtype (RAMP-like) (HMM-CLUST) |
| | GenProp0469: CRISPR system, Dpsyc subtype (HMM-CLUST) |
| | GenProp0768: CRISPR system, Pging subtype (HMM-CLUST) |
| | GenProp0685: CRISPR system, Cyano subtype (HMM-CLUST) |
