HMM Summary Page: TIGR00302

Functionphosphoribosylformylglycinamidine synthase, purS protein
Gene SymbolpurS
Trusted Cutoff39.00
Domain Trusted Cutoff39.00
Noise Cutoff37.50
Domain Noise Cutoff37.50
Isology Typeequivalog
HMM Length80
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004642: phosphoribosylformylglycinamidine synthase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH, Loftus BJ
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn species such as Bacillus subtilis in which FGAM synthetase is split into two ORFs purL and purQ, this small protein, previously called yexA, is required for FGAM synthetase activity. Although the article does not make it clear whether this is a subunit or an accessory protein, it is encoded as part of the operon, which suggests stochiometric amounts, = subunit.
ReferencesSE TIGR GA hmmls RM 10784038 RT The yexA gene product is required for phosphoribosylformylglycinamidine synthetase activity in Bacillus subtilis. RA Saxild HH, Nygaard P. RL Microbiology 2000 Apr;146 ( Pt 4):807-14
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)