Accession | TIGR00324 |
Name | endA |
Function | tRNA-intron lyase |
Gene Symbol | endA |
Trusted Cutoff | 59.60 |
Domain Trusted Cutoff | 59.60 |
Noise Cutoff | 47.60 |
Domain Noise Cutoff | 47.60 |
Isology Type | equivalog |
EC Number | 4.6.1.16 |
HMM Length | 177 |
Mainrole Category | Transcription |
Subrole Category | RNA processing |
Gene Ontology Term | GO:0000213: tRNA-intron endonuclease activity molecular_function |
| GO:0000214: tRNA-intron endonuclease complex cellular_component |
| GO:0006388: tRNA splicing, via endonucleolytic cleavage and ligation biological_process |
Author | Loftus BJ |
Entry Date | Apr 20 1999 2:07PM |
Last Modified | Jul 7 2014 1:34PM |
Comment | The enzyme catalyses the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate termini. The genes are homologous in Eucarya and Archea. The two yeast genes have been functionally studied (see MEDLINE; 97344075) and are two subunits of a heterotetramer enzyme in yeast the other two subunits of which have no known homologs. |
References | RM 97344075
RT Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal tRNA intron processing systems.
RA Kleman-Leyer K, Armbruster DW, Daniels CJ
RL Cell 1997 Jun 13;89(6):839-47
SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_01834; 9 of 12 |