HMM Summary Page: TIGR00326

Functionriboflavin biosynthesis protein RibD
Gene SymbolribD
Trusted Cutoff156.35
Domain Trusted Cutoff156.35
Noise Cutoff152.80
Domain Noise Cutoff152.80
Isology Typeequivalog
EC Number3.5.4.26
HMM Length343
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryRiboflavin, FMN, and FAD
Gene Ontology TermGO:0008703: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity molecular_function
GO:0008835: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity molecular_function
GO:0009231: riboflavin biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the ribD protein as found in Escherichia coli. The N-terminal domain includes the conserved zinc-binding site region captured in the HMM dCMP_cyt_deam and shared by proteins such as cytosine deaminase, mammalian apolipoprotein B mRNA editing protein, blasticidin-S deaminase, and Bacillus subtilis competence protein comEB. The C-terminal domain is homologous to the full length of yeast HTP reductase, a protein required for riboflavin biosynthesis. A number of archaeal proteins believed related to riboflavin biosynthesis contain only this C-terminal domain and are not found as full-length matches to this model.
ReferencesDR PROSITE; PDOC00702; DR PFAM; PF00383; dCMP_cyt_deam; DR PFAM; PF01872; RibD_C; DR ECOCYC; EG11321; ribD; SE TIGR GA hmmls
Genome PropertyGenProp0112: riboflavin, FAD and FMN from GTP and ribulose-5-P (HMM)
GenProp0112: riboflavin, FAD and FMN from GTP and ribulose-5-P (HMM)