| Accession | TIGR00331 |
| Name | hrcA |
| Function | heat-inducible transcription repressor HrcA |
| Gene Symbol | hrcA |
| Trusted Cutoff | 197.20 |
| Domain Trusted Cutoff | 197.20 |
| Noise Cutoff | 119.75 |
| Domain Noise Cutoff | 119.75 |
| Isology Type | equivalog |
| HMM Length | 338 |
| Mainrole Category | Regulatory functions |
| Subrole Category | DNA interactions |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0009408: response to heat biological_process |
| | GO:0016566: specific transcriptional repressor activity molecular_function |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:08PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures.
In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene. |
| References | RM 96165263
RT hrcA, the first gene of the Bacillus subtilis dnaK operon encodes a negative regulator of class I heat shock genes.
RA Schulz A, Schumann W
RL J Bacteriol 1996 Feb;178(4):1088-93
SE TIGR
DR HAMAP; MF_00081; 252 of 260 |
| Genome Property | GenProp0244: chaperone system: DnaK-DnaJ-GrpE (HMM) |
