HMM Summary Page: TIGR00331

Functionheat-inducible transcription repressor HrcA
Gene SymbolhrcA
Trusted Cutoff197.20
Domain Trusted Cutoff197.20
Noise Cutoff119.75
Domain Noise Cutoff119.75
Isology Typeequivalog
HMM Length338
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0009408: response to heat biological_process
GO:0016566: specific transcriptional repressor activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentHrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene.
ReferencesRM 96165263 RT hrcA, the first gene of the Bacillus subtilis dnaK operon encodes a negative regulator of class I heat shock genes. RA Schulz A, Schumann W RL J Bacteriol 1996 Feb;178(4):1088-93 SE TIGR DR HAMAP; MF_00081; 252 of 260
Genome PropertyGenProp0244: chaperone system: DnaK-DnaJ-GrpE (HMM)