|Domain Trusted Cutoff||106.80|
|Domain Noise Cutoff||69.65|
|Mainrole Category||Purines, pyrimidines, nucleosides, and nucleotides|
|Subrole Category||Pyrimidine ribonucleotide biosynthesis|
|Gene Ontology Term||GO:0004588: orotate phosphoribosyltransferase activity molecular_function|
| ||GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process|
|Entry Date||Apr 20 1999 2:09PM|
|Last Modified||Feb 14 2011 3:27PM|
|Comment||Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate (OMP) in the presence of divalent cations, preferably Mg2+.
In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC 188.8.131.52). The combined activity of EC 184.108.40.206 and EC 220.127.116.11 is termed uridine 5'-monophosphate synthase.
The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme.|
|References||DR PROSITE; PDOC00096;
DR ECOCYC; EG10808; pyrE;
DR HAMAP; MF_01208; 248 of 300|
|Genome Property||GenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)|
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